Anti-Proliferative Effect of Brusatol and Brucein D on Human Breast Cancer Cells

JULS Volume 10, Issue 1

Natalia Marta Blicharska1, Lin Zhixiu2

1 Department of Pharmacology, University of Toronto, Toronto, Canada
2 School of Chinese Medicine, Chinese University of Hong Kong

Corresponding Author: Natalia Marta Blicharska (n.blicharska@mail.utoronto.ca)

Abstract

Breast cancer is the leading cause of cancer-related deaths in women. Metastatic breast cancer (MBC) is a difficult disease to treat and patients diagnosed with MBC often succumb to the disease. The difficulty in treating MBC is due to the heterogeneity of breast cancers which limits the number of effective treatment options available to patients and due to the development of chemoresistance in breast cancer cells. As a result, it is imperative to identify and develop new anti-cancer agents that can provide additional treatment options to patients diagnosed with breast cancers. Recent studies have demonstrated the anti-proliferative effects of Brusatol and Brucein D, two quassinoids isolated from Brucea javanica, in multiple cancer cell lines. The present study tests the anti-proliferative effects of Brusatol and Brucein D in two human breast cancer cell lines: MDA MB-231 and MCF-7. Results of MTT assays determine that both Brusatol and Brucein D exhibit concentration-dependant anti-proliferative effects in MDA MB-231 and MCF-7 breast cancer cells lines.