Senior Editor Application Personal Information Name: Phone Number: Email: Year of Study: Program(s) of Study: Resume Please upload your curriculum vitae (CV) as a PDF, DOC, or DOCX, outlining academic, research and other co-curricular experiences and skills. Questions 1. What unique skills would you bring to your role as senior editor? 2. In your opinion, what aspects can be improved in this year's issue of JULS, and how would you go about improving them? 3. How much time can you commit to JULS during the school year? What other commitments will you have in the upcoming year (e.g. extracurriculars, employment, etc.) 4. Do you have any past experience managing a student group or similar organization? If so, please describe what you have learned from this position and how you plan on applying it to your role as a senior editor. Passages Please choose ONE of the following passages and make some suggestions for improving it. We recommend you copy the text to a Microsoft Word document, and track changes. DO NOT MAKE EDITS DIRECTLY IN THIS APPLICATION FORM. Please upload the edited Word document with your changes. Edited Passage (.doc, .docx, .pdf files are accepted): Molecular Biology: The smallest of the URF's (URFA6L), a 207-nucleotide (nt) reading frame overlapping out of phase the NH2-terminal portion of the adenosinetriphosphatase (ATPase) subunit 6 gene has been identified as the animal equivalent of the recently discovered yeast H+-ATPase subunit 8 gene. The functional significance of the other URF's has been, on the contrary, elusive. Recently, however, immunoprecipitation experiments with antibodies to purified, rotenone-sensitive NADH-ubiquinone oxido-reductase (hereafter referred to as respiratory chain NADH dehydrogenase or complex I) from bovine heart, as well as enzyme fractionation studies, have indicated that six human URF's (that is, URF1, URF2, URF3, URF4, URF4L, and URF5, hereafter referred to as ND1, ND2, ND3, ND4, ND4L, and ND5) encode subunits of complex I. This is a large complex that also contains many subunits synthesized in the cytoplasm. Physiology: VEGF is the most potent and direct factor in the induction of angiogenesis and collateral formation. In the present study, VEGF mRNA expression was highest in the 40 HZ group and also significantly increased in the 10 Hz group compared with the control group. The most potent stimuli that initiate capillary angiogenesis are ischemia and hypoxia demonstrated that hypoxia is a potential cause for the increases in VEGF that occur with chronic motor nerve stimulation of skeletal muscle. The level of VEGF mRNA was highest in the 40 Hz group. The main mechanism for this upregulation is most likely related to the hypoxic–ischemic state. When blood flow to the muscles is reduced during static contraction, an imbalance between oxygen supply and demand is created. This elicits the production of ischemic metabolites, including VEGF. Chemistry: Studies on the disposition of labetalol stereoisomers in humans after oral administration of the racemic labetalol mixture have shown predominance of the (S,S)-stereoisomer in plasma and urine and small concentrations of the (R,R) and (S,R) stereoisomers in plasma. The proportion of the (R,S) and (R,R) stereoisomers is respectively 22 and 9% in plasma and 4 and 24% in urine, respectively, suggesting streoselective renal clearance. Previous experiements observed that the concentrations in plasma of (R,R)-labetalol was approximately 40% lower than those of the other stereoisomers, confirming the fact that the kinetic disposition of labetalol is stereoselective. Concentrations of three of the four stereoisomers of labetalol are higher in women than men. Concentrations are similar between genders, however, for the b-blocking stereoisomer (R,R-labetalol), possible explaining the similarity in antihypertensive response to the drug. Would you be willing to accept an alternate executive position if offered one? YesNo *Note: If you receive error code 2 after submitting, please save your answers in a separate document and re-submit after refreshing the page.